Khem A Karira, Mohammad Saleh Soomro.
Apolipoprotein as an Indicator of Coronary Artery Disease Risk in Normolipidemic Subjects after Myocardial Infarction.
J Coll Physicians Surg Pak Jan ;10(8):281-3.

The study investigated whether apolipoprotein (apo) A-I and B could better identify patients than lipid lipoproteins in a male population with recent acute myocardial infarction which could differentiate normolipidemic subjects with an increased risk of myocardial infarction. Serum lipids, HDL-C, LDL-C and apo A-I and B were determined in 34 hyperlipidemic and 31 normolipidemic survivors of myocardial infarction and compared with matched control. A significant decreased level of HDL-C and apo A-I (P<0.01,P<0.05) and an increased level of LDL-C and apo B (P<0.001,P<0.05) was found in all the patients. The data supports the view that apo A-I and B as well as its ratio (X2 values 11.11,18.84 and 28.51 respectively, P<0.001) were better indicators of lipid derangement in normolipidemic survivors of myocardial infarction than the levels of LDL-C and HDL-C. Our findings also suggests that determination of apo A-I and B and its ratio are better predictors of coronary artery disease even in patients with normal plasma lipid level.

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