Jahangir Sarwar, Jawad Zahir, Asifa Dian.
Laparoscopic cholecystectomy.
Professional Med J Jan ;16(3):321-6.

Objective: To determine if intraoperative instillation of bupivacaine into gall bladder fossa would decrease early postoperative pain after laparoscopic cholecystectomy, Design: Double-blind, randomized, controlled trial. Setting: Surgical Unit-I, Holy Family Hospital, Rawalpindi and Surgical Unit-1, Benazir Bhutto Hospital, Rawalpindi. Duration: Two year study. Patients: Fifty patients underwent laparoscopic cholecystectomy group-A. They were compared with a control group of fifty patients who had laparoscopic cholecystectomy but did not receive bupivacaine Group-B. Intervention: Instillation of 10 ml of 0.5% bupivacaine into gall bladder fossa intra operatively after removal of gall bladder. Main Outcome Measures: Visual analogue scale (VAS) pain scores assessed 3 times post operatively, at 1, 6 & 24 hours, using similar peroperative and postoperative analgesics in both groups. Main Outcome Measure: Mean VAS pain scores (range 0 [no pain] to 10 [severe pain]) at 1 hour and at 6 hours after surgery were 6.5 and 4.2 respectively, in the bupivacaine group (Group-A) compared with 6.2 and 4.5 respectively, in the control group(Group-B) (p =.085 and 0.078,sd=.919 and.495). VAS scores at 24 hours postoperatively did not differ between the two groups (2.4 VS 2.5)(p=.282,sd=.636). Conclusion: Instillation of bupivacaine into gall bladder fossa has no effect on post operative pain control in elective laparoscopic cholecystectomy

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com