Aizza Zafar, Hasan Ejaz, Tanzeem Akbar Cheema.
Antimicrobial suseptibility pattern in urinary tract infections.
Pak Paed J Jan ;33(2):103-7.

Objective: To find out common uropathogens and their sensitivity pattern. Design: Prospective study. Place and Duration of Study: This study was conducted at The Children’s Hospital and Institute of Child Health, Lahore over a four months period from October 2007 to January 2008. Materials and Methods: A total of 100 positive culture samples with >105 CFU/ml were studied. Results: The analysis of samples for pathogenic bacteria revealed E.coli and Klebsiella (37% each) followed by Pseudomonas (23%), Acinetobacter, Proteus and Staphylococcus aureus (1% each). The organisms isolated in this study showed variable antimicrobial susceptibility to different antibiotics: Imipenem (98%), Nitrofurantoin (91%), Ceftizoxime (85%), Ciprofloxacin (76%), Ceftazidime (70%) and Amoxicillin+Clavulanate (60%). E.coli showed good sensitivity to Imipenem and Nitrofurantoin (100% each), Ceftizoxime (85%), Amoxicillin+Clavulanate (75.7%) and Ciprofloxacin (73%). Klebsiella was susceptible to Imipenem and Nitrofurantoin (97.3% each), Ceftizoxime (92%) and Ciprofloxacin (70.3%). Pseudomonas showed maximum sensitivity to Imipenem (95.7%), Ciprofloxacin (91.3%) and Ceftazidime (82.6%). A significant antimicrobial susceptibility pattern of E.coli and Klebsiella was seen with amoxicillin+clavulanate and nitrofurantoin (p 0.015 and <0.001 respectively) when compared to Pseudomonas. Klebsiella showed high resistance while E. coli and Pseudomonas better susceptibility with cefixime (p 0.03). Conclusion: E.coli, Klebsiella and Pseudomonas were the most common causative agents of urinary tract infections. The preferred antibiotics against these uropathogens were Imipenem, Nitrofurantoin, Ceftizoxime, Ceftazidime and Ciprofloxacin.

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