M Mirajullah, Shen Xinya, Liu Caidong, Wang Yujiang.
Cornucopia of Cultured Schwann Cells: Where is the Best Source in Albino Rats?.
J Ayub Med Coll Abottabad Jan ;13(4):3-6.

Background: Schwann Cells (SC) are multifunctional glia cells with diversified biological potentials. To study their biological activities ample amount of cultured SC is a pre-requisite. Many sources have been exploited in the past for SC culture but unfortunately no attempt has been made to find the richest source. Methods: To make an attempt in this direction, we cultured SC under identical conditions from various neural sites in the neonate & young SD albino rats. Fresh, cryopreserved & pre-stimulated neural tissue, have been compared for total & % of SC/Unit tissue from the combined data of living & immunostained cultures. Results: Our data shows that the upper limb nerves have not only quantitative advantage (2.35e4 cells/mg tissue) but also have significant qualitative edge (P<0.05-0.01) over the remaining sources. It can be concluded from our data that upper limb nerves are the best available source for SC/unit tissue.

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