Salma Attaullah, Rahim Bangash, Aman Ullah, Zahoor Ahmed, Jamilur Rehman.
Inherited dyslipidaemic disorders contributing to coronary heart disease.
J Ayub Med Coll Abottabad Jan ;20(4):90-3.

Background: Lipoprotein (a) [Lp (a)] is an established independent risk factor for premature myocardial infarction (MI)/coronary artery disease (CAD). The study was conducted to determine the value of Lp (a) in prediction of CAD or MI in the offspring at risk. Methods: A total of 160 subjects were investigated. Serum Lp (a) was measured by ELISA, serum total cholesterol, triglycerides (TG) and HDL-Cholesterol by enzymatic colorimetric methods using standard kits. Results: Differences in levels of total Lp (a) and cholesterol were observed between patients and controls. Both Lp (a) (16.23±1.95 mg/dL) and cholesterol (175.00±7.60 mg/dL) of group A (patients) were higher than the corresponding controls. However an opposite trend in results was noted for serum HDL-Cholesterol in patients vs. controls. Conclusion: Persons found to have elevated levels of Lp (a) should focus on controlling the known modifiable risk factor for heart disease, especially smoking, hypercholesterolemia, obesity, hypertension and sedentary life style.

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