Uruj Zehra, Mohammad Tahir, Fahim Haider Jaffari.
Ginkgo Biloba induced malformations in kidney of mice - a light microscopic study.
Ann Pak Inst Med Sci Jan ;4(1):23-30.

Objective: To see the effects of ginkgo biloba on developing kidneys of mice. Subjects and Methods: This Experimental study was carried out at University of Health Sciences, Lahore from May to December 2006. Two experimental (A and B) and one control (C) groups of pregnant albino mice (six in each group) were kept under standard conditions of temperature and environment. Human therapeutic dose of standardize exhact of ginkgo biloba was given to group A, high dose to group B and distilled water to group C were given throughout gestational period. Forty-nine fetuses from B and C groups and fifty fetuses from A group were obtained. They were dissected; the kidneys were removed, stained with H&E and PAS and observed under light microscope. Statistical analysis was carried out by using SPSS version 13. Results: Proximal and distal convoluted tubules were found to be disrupted in treated groups. The diameter of the renal corpuscles was also increased in these groups. The treated groups showed dose related response, Conclusion: This research proves the harmful effects of ginkgo biloba on development of kidneys in mice.

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