Ghazala Nasreen, Malik Amjad Yasin, Abeera Choudry.
Induction of labour comparison of oral misoprostol with vaginal misoprostol for cervical ripening.
Professional Med J Jan ;18(2):181-8.

Subjects and methods: 100 females between 37-42 weeks of gestation were randomly divided into two groups 1and 2. Patients in group -1 assigned to the stepwise oral misoprostol arm received 50 μg initially followed by 100 μg every 04 hours upto maximum 04 doses ; group-2 assigned to the vaginal misoprostol arm received 25 μg every 04 hours up to maximum 04 doses. Subsequent doses of misoprostol were withheld if adequate uterine activity (≥3 contractions in 10 minutes) or a Bishop score ≥ 8 had been achieved, or active labour had begun. The main outcomes were the interval from first misoprostol dose to delivery and mode of delivery. Patients were also monitored for adverse events. Results: There was no difference in the average interval from the first dose of misoprostol to delivery in the oral (21.1 +/- 7.9 hrs) and vaginal (21.5 +/-11.0 hrs, p = NS) misoprostol groups. 9 patients in the oral group (18%) and 16 patients in the vaginal group (32%) underwent caesarean section (p<0.05). There were no significant differences in the occurrence of tachysystole, hypertonus, hyperstimulation or neonatal outcome between two groups. Conclusions: Oral misoprostol appears to be as effective as vaginal misoprostol for cervical ripening with a low incidence of hyperstimulation, no increase in side effects, and is associated with a lower cesarean section rate.

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