Afifa Waheed, Nabeela Shami.
Preterm labour effectiveness of transdermal glyceryl trinitrate patch.
Professional Med J Jan ;18(2):174-80.

Sample size: Fifty pregnant women with preterm labour were included in the study. Results: 54% of pregnant women were between G2 - G4. Majority (48%) of the women presented between 31 - 34 weeks of gestation. 46% of pregnant women had bishop score of 4 or more. 64% of patients found to have no risk factor for preterm labour. Majority (86%) responded after application of second patch (10 mg glyceryl trinitrate patch). 84% had no side effects. Local skin reaction (10%) and headache (4%) observed in few patients. 58% of pregnant women delivered after 48 hours and 78% of them delivered vaginally which was statically significant and majority of babies delivered weight more than 1.5 kg and with good Apgar score. Conclusions: It is concluded from the study that glyceryl trinitrate is a safer tocolytic, which has simple method of application; rapid onset of action with low cost, low risk from side effects and it does not require intensive monitoring.

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