Premenstrual tension is characterised with the water retention probably caused by rise in secretion of oestradiol. Oestradiol stimulates the secretion of vasopressin on the specific day of manstrual cycle in human and oestrous cycle in rats leading to water retention. Furthermore, oestradiol is reported to stimulate the activity of enzyme, orntthine decarboxylase, which is followed by elevation of plasma vassopressin secretion in the midcycle. In aseries of experiments, an inhibitor of ornithine decarboxylase, difluoromethyl ornithine has proved to inhibit water retention. Thus, a cascade of hormonal and enzymic events sets a rhythm to cause water retension leading to premenstrual tension syndrome.
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