Sayed Zafar Hassan, Arif Raza Khan, Ajmal Hussain, Farman Ali, Shahe Din.
Clinical profile of carcinoma larynx in 50 adult patients.
J Med Sci Jan ;19(2):78-81.

Objective: To study the clinical profile of carcinoma larynx in adult patients admitted to a tertiary care hospital in Peshawar. Material and Methods: The study was conducted in the Department of Otorhinolaryngology, Khyber Teaching Hospital, Peshawar from January 2007 to December 2009. Fifty newly diagnosed cases of carcinoma larynx were included in the study. A detailed history was taken and a thorough physical examination performed on every patient. All patients were investigated with indirect laryngoscopy, direct microlaryngoscopy, CT scan/MRI and findings recorded on standard proforma. The results were analyzed using SPSS version 10. Results: Out of 50 patients, 47 (94%) were male and 3 (6%) were female. The majority of patients were between 50-60 years of age. The age range was 40-70 years with a mean age of 51.27 years. The main symptoms were hoarseness (90%), globus or foreign body sensation (60%), neck lump (54%), and stridor in 20 (40%). Forty-one patients (82%) were smokers. None used alcohol and only 5 (10%) patients had a family history of laryngeal carcinoma. Clinically 62% patients presented with stage 1 and 2, and 38% with stage 3 and 4 disease. The most common site was the glottic region (44%), followed by transglottic (32%), supraglottic (22%) and subglottic area (2%). Conclusion: Carcinoma larynx is significantly more common in males who smoke. Early recognition of carcinoma larynx is a key factor to minimize the mortality and morbidity.

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