Jamila Mnaib, Bilqis Afridi.
Comparison between misoprostol and extra amniotic Pgf2a for midtrimester pregnancy termination.
J Med Sci Jan ;17(2):67-70.

Objectives: To compare the efficacy of Misoprostol with extra amniotic PGF2á for mid trimester pregnancy termination. Materials and Methods: This study was conducted in the Department of Gynaecology & Obstetrics, Unit B, Khyber Teaching Hospital, Peshawar, from January 2004 to June 2005. A total of 200 patients were included in the study. These patients needing mid trimester termination of pregnancy were alternately placed into two groups: Group A to receive Misoprostol 400 micro grams 4 hourly, vaginally and group B to receive injection PGF2á extra amniotically. The primary outcome measures were, induction-expulsion interval, need for surgical intervention and post termination complications. The exclusion criteria were history of more than one caesarian section and previous myomectomy. Results: Mean induction – delivery interval for Group-A (Misoprostol group) was 10.6 hours as compared to 17.03 hours for Group-B (PGF2á. group). Fifty-four percent of patients in group A needed surgical evacuation as compared to 63% in group B. Better patient compliance was seen with Misoprostol group. The extra amniotic PGF2á injection was associated with more discomfort, pain, restriction of mobility, bleeding and infection. Conclusion: Both Misoprostol and PGF2á are safe and effective for termination of mid trimester pregnancy. Misoprostol is associated with a better outcome, leading to shorter hospital stay, lesser expense and less burden on hospital staff.

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