Raj Kumar Chohan, Jagdesh Kimar, Shah Murad.
Role of oral antidiabetic agents in type-2 diabetes mellitus patients.
Pak J Med Health Sci Jan ;5(1):60-3.

Objective: Study was planned to examine and compare the effects of oral antidiabetic drugs in type 2 diabetes mellitus patients. Design: Prospective and comparative study. Place and duration of study: Study was conducted at the department of Pharmacology, Basic Medical Sciences Institute (BMSI) in collaboration with Medical Department, Jinnah Postgraduate Medical Centre (JPMC) Karachi, from January 2006 to July 2006. Patients and methods: After scrutinized sixty newly untreated type 2 Diabetes Mellitus patients were enrolled in this study. Females and Males patients were divided in two groups. In Group-I(n=27)patients were treated with drug pioglitazone 15mg after meal. In group-II (n=33) patients were treated with drug glibenclamide 5mg early morning just before breakfast. Patients with peptic ulcer, renal diseases, hepatic diseases, blood diseases, any serious complications were excluded from this study. General Physical examination, pulse, blood pressure, routine investigation etc. was recorded at the time of patients enrollment and same assessments was taken at day 45 and at day 90. Fasting and Random Blood Sugar was calculated by Glucose-Oxidase Enzymatic method. Procedure was explained to patients and written consent was obtained on proforma which was especially designed for research. The data were expressed as the Mean+SEM at the end of study and was analysis by paired “t” test. Results: Difference between two groups at the end of study shows better results in given parameters. FBS Parameter at day 0 mean values were 188.42+12.05mg/dl at day 90 140.06+ 5.68mg/dl. P value from day 0 to day 90 was P<0.05*(Significant). In parameter RBS at day 0 mean values were 284.18+17.05mg/dl and at day 90 170.94 + 5.80 mg/dl. P-Value from day 0 to day 45 was P<0.005**(Moderate significant) and from day 45 to day 90 P-value was P<0.002**(Moderate Significant),better results obtained from group-II with drug glibenclamide at the end of study. Conclusion: Drug glibenclamide controlled type-2 diabetes mellitus by decreasing blood sugar level in a given study period as compared with other our study drug pioglitazone.

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