Aamir Ijaz, Farooq Ahmad Khan, Dilshad Ahmad Khan, Syed Azhar Ahmad.
Lipoprotein(a) of hydrogenated cottonseed oil and palm oil in comparison with corn oil.
Pak J Pathol Jan ;8(4):8-14.

Lipoprotein(a) [Lp(a)] is considered an independent risk factor for coronary heart disease because of its thrombogenic and atherogenic properties. Effects of dietary palm oil (PO) on serum Lp(a) levels in human volunteers were studied in comparison to hydrogenated cottonseed oil (HCSO). Fifty one healthy adults (males = 28; females= 23), 20-68 years of age, were included in the study. The protocol of various types of dietary oils given to the individuals was as following: initially Corn Oil (CO) (2 months) followed by PO (4 months) then CO (2 months) followed by HCSO (4 months). Blood samples were collected after every two months and analyzed for serum Lp(a) by ELISA method using TinteElize (Sweden) kits. Results of Lp(a) showed considerable individual variations. There was a non- significant rise of serum Lp(a) levels in the two samples of PO period (161 mg/L and 178 mg/L) as compared to the basal samples (159mg/L). Lp(a) levels after HCSO diet was 315 and 354 mg/I after two and four months respectively (p < 0.01). It is concluded that HCSO diet caused marked rise in Lp(a) levels while no significant change was observed after PO diet.

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