Asma Samee, Muhammad Waqar Rabbani, Tariq Aziz.
Sedative premedication in children undergoing elective endoscopy under general anesthesia at the Children's hospital and the Institute of Child Health Multan.
Pak Paed J Jan ;35(4):192-6.

Objective: To compare the effectiveness and safety of promethazine and midazolam as sedative premedication in children undergoing elective endoscopy under general anesthesia at The children’s Hospital & The Institute of child Health Multan. Study Design:Randomized controlled trial Place and Duration of study: Endoscopy unit, The Children’s Hospital &The Institute of Child Health, Multan from February 2009 to January 2010. Methodology: 100 children (1 to 6 years of age) scheduled for elective endoscopy under general anesthesia, fulfilling inclusion and exclusion criteria were included. During pre-anesthetic assessment before endoscopy, fasting protocol and sedative premedication were explained to the parents and informed consent was taken.Patients were divided in two groups, group A taking oral promethazine and group B oral midazolam. Effectiveness of the drugs was measured by Sedation Grades, based on calmness and co-operation of the child at the time of separation and shifting to operation room, acceptance of face mask and reaction to intravenous cannulation. A structured proforma was designed to record all information and results were prepared according to the working definitions. Side effects if any were also noted. Results: Out of 50 children who received promethazine, 20( 40%) showed complete effectiveness. In midazolam group, 39 (78%) children showed complete effectiveness and one patient was over sedated. Conclusion: Midazolam effectively relieve separation anxiety at shifting to operation room and makes the child very compliant at the time of face mask placement and intravenous cannulation as compared to promethazine.

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