Parvaiz A. Shah, Saeed Asgher, Nadeem lrfan, Naveed Akhta.
Comparison of Locally available Gum in Co-trimoxazole test formulation with Standard Formulation: In vitro and In-vivo Evaluation.
Mother & Child Jan ;34(2):75-9.

The six commercially available gums were selected and on the basis of solubility, swelling, odour, sedimentation and fungal growth, the gum tragacanth, Acacia and almond gum were considered for further study Aqueous solution of 4%, 5% and 6% of each selected gum were prepared and rheograms were drawn.Almond gum was found to be good in the physical characteristics as well as on theology basis, so it was incorporated as a suspending agent in co-trimoxazole suspension instead of synthetic suspending agent. Thereby, compared with three brands of well known co-trimoxazole suspension. The pH of three bands and test formulation was found to be within the range. The viscosity of test formulation was observed to be greater than Bactipront and comparable with Bactrim and Septran.In sedimentation study test formulation was found to be best because it did not showed any separation. For stability evaluation, viscosity measurement was carried on at 28oC, 40oC and 50C for fifteen days. All the products showed decrease in viscosity at 40oC and 50C but test formulation decrease in viscosity was less than Bactipront and Septran.For in vivo comparison the bidavailability parameters, time to reach peak plasma concentration, the first moment of plasma concentration time curve, absorption half life and mean residence time of formulation III were similar statistically with formulation I but peak plasma concentration. Area under the curve and Absorption rate constant of formulation III were statistically different with formulation I. When formulation III was compared with formulation II it was seems to be similar in all bioavailability parameters except peak plasma concentration.For in vivo comparison the bidavailability parameters, time to reach peak plasma concentration, the first moment of plasma concentration time curve, absorption half life and mean residence time of formulation III were similar statistically with formulation I but peak plasma concentration. Area under the curve and Absorption rate constant of formulation III were statistically different with formulation I. When formulation III was compared with formulation II it was seems to be similar in all bioavailability parameters except peak plasma concentration.In case of disposition parameters the values of formulation 111 were statistically similar with formulation I in all the parameters like elimination half life, the elimination rate constant, zero time plasma concentration, apparent volume of distribution and total body clearance. When formulation III was compared with formulation II the value of elimination half life and apparent volume of distribution were found to be similar, while there was statistically difference in the elimination rate constant, zero time plasma concentration, and the total body clearance values.

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