Abdulmoneim Al Agha.
Pseudohypoaldosteronism, hypothyroidism and hypoparathyroidism in a two-year-old boy.
Pak Paed J Jan ;35(3):175-7.

A two-year-old boy, found to have a persistent hyperkalemia, hyponatraemia with metabolic acidosis in addition to repeated episodes of apnoeic attacks secondary to low serum calcium. Except for failure to thrive, his physical examination was within normal. Laboratory values confirmed the unusual combination of pseudohypoaldestronism, hypoparathyroidism and congenital hypothyroidism. Renal function was normal. Hormonal evaluation revealed normal cortisol, as well as 17- hydroxyl progesterone which were done to exclude the possibility of congenital adrenal hyperplasia as the cause of electrolyte disturbance. In the absence of aldosterone deficiency or renal dysfunction, it was assumed that this infant had primary renal resistance to aldosterone, known as pseudohypoaldestronism. We attempted to report an unusual combination of persistent yet 3 endocrinopathies in closely related parents.

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