Shaafia Fatima, Hafsa Muhammad, Ayesha Arif.
Nephrogenic diabetes insipidus.
Pak Paed J Jan ;35(3):169-70.

Congenital nephrogenic diabetes insipidus is a rare disorder in which the kidney is insensitive to antidiuretic hormone. It is mostly because of mutation in vasopressin type 2 receptor gene. Few cases have been reported with incidence of 3 in 100,000. We report here a case of an 11 month old infant who presented in emergency with dehydration, excessive cry, polyuria, polydipsia and constipation. During hospital stay detailed history, clinical examination and laboratory investigations suggest diagnosis of nephrogenic diabetes insipidus. He was administered on thiazide diuretics after which infant showed improvement.

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