Syed Millat Hussain.
Nalbuperine for felief of Labour Pain in Primiparous Women.
Mother & Child Jan ;35(2):62-6.

The analgesic efficacy and safety of Butorphanol 2mg (BUT-2) and nalbuphine hydrochloride 15mg (NAL-15) administered intramuscularly were compared in randomized, double blind clinical trail in sixty pregnant women with labour pain. Pain relief was measured by a 4 point verbal rating scale, 10,20,30,45 and 60 minutes after administration of drug. The average total pain relief (TOTPAR) score within first hour was 1.8 with BUT-2 and 1.7 with NAL-15 (P < 0.05). NAL-15 was associated with higher frequency of adverse events and significantly lower respiratory rate in neonates. The results indicate) that BUT-2 is as effective as NAL-15 but has a superior safety profile.

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