Rukhshan Khurshid, Atiya Abbasi.
Role of Cathepsin D, S and L in Breast Cancer.
Mother & Child Jan ;13(3):89-93.

There is considerable interest in proteolytic enzyme owing to their potential and experimentally documented involvement in invasiveness metastatic processes. Cathepsins usually have endopeptidase as well as exopeptidase activity and ubiquitously activity distributed in all cells at low concentration. It is proposed that over expression of these proteases may be one of the factors responsible for metastasis in breast cancer. The present study was conducted to study the levels and activity of Cathepsins among 100 patients of breast cancer. The levels as well as activity of Cathepsins was significantly higher among patients as compared to the controls.

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