Rukhshan Khurshid, Abdul Baser.
An Apparent inverse relationship between Serum Cholesterol and Cancer of Breast and other sites.
Mother & Child Jan ;37(3):81-7.

Recent findings have raised questions about the relationship of low serum cholesterol to subsequent morbidity and mortality. Present study was planned to discover a relationship between serum cholesterol level and cancer of different sites including oral site, G.I.T., lung and breast in 106 middle aged male and female. An attempt was also made to identify the levels of HDL and LDL cholesterol, total lipid, phospholipid and triglycerides. Of the 106 patients 38 had cancer of oral sites, 22 with cancer of G.I.T., 26 of lung and 20 were identified with breast cancer. 30 control subjects (18 males and 14 females) were included in the study. Serum cholesterol, phospholipid, total lipid and LDL cholesterol were significantly decreased in both sexes when compared with control subjects. No remarkable difference was observed in the level of cholesterol phospholipid molar ratio and triglyceride. Serum HDL cholesterol level was increased in both sexes but no significant difference was observed. An inverse relationship was observed between cholesterol level and cancer of different sites. From this study it is concluded that an association between low cholesterol level and cancer of different sites in not responsive of an etiologic link between low serum cholesterol and cancer but reflects advance in the clinical course of cancer.

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