Salma Haq, Farzana Amjad, Ayesha Yazdani Malik, AH Nagi.
A Quantitative Analysis of Circulating Tumour Markers in Epithelial Malignancies (Evaluation of Combined Efficacy of CEA and TPA).
Mother & Child Jan ;37(3):92-7.

The present study evaluates the efficacy of combined estimation of two important markers of epithelial malignancies I.e. Carcinoembryonic Antigen (C.E.A) and Tissue Polypeptide Antigen (T.P.A.) with regard to their relation with clinical stage of the patients and effect various treatment modalities. Serial marker levels were estimated in 65 patients suffering from epithelial malignancies in different locations including carcinoma of cervix (n =14) breast (n=20),Colorectal region (n=15) and urinary bladder (n=16). Raised C.E.A. and T.P.A levels were seen in 76%, 65%, 73% and 75% cases of carcinoma of cervix, breast, colorectal and urinary bladder respectively. During follow up serial tumour marker estimations showed that effective therapy resulted in raised marker levels returning to normal while subsequent elevation developed with tumour recurrence or spread. Combination of C.E.A. and T.P.A. is complimentary as they reflect two different aspects of tumour growth and their combined use improves the diagnostic value in the management of cancer patients.

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