Abid Naeem, Tahira Jabbar.
Low dose heparin; therapeutic benefit in postpartum cerebral venous thrombosis.
Professional Med J Jan ;19(2):246-50.

Objective: To evaluate the therapeutic benefit of low dose heparin in cerebral venous thrombosis, occurring during period of perpeurum. Study design: Descriptive study. Setting: Department of Medicine DHQ Hospital Mirpur (Department of Obs/Gynae DHQ Hospital Mirpur(AK). Period: January 2010 to November 2011. Method: This study was carried on 100 patients with history of postpartum cerebral venous thrombosis. Out of which 48 on heparin and 52 formed the control group. The ages of all patients were between 20 to 30 years. Parameter recorded included history. Blood pressure.,the diagnosis was supported by cranial computed tomography. The secondary causes were ruled out on the basis of history and physical examination. The data and results were analyzed in SPSS. Results: Out of 48 patients in heparin group 30 with non-heamorrhage lesion and 18 with haemorrhagic infarction). 52 in control group. 34 non-haemorriagic lesion and 18 with haemorragic infarct .in non-haemorrhagic CVT, there is no death in heparin group as compared to 5 deaths in control group. In patients with haemorriagic lesions, there were 5 deaths in heparin group as compared to 7 deaths in the control group. Heparin faed better than the control group, both in patients with haemorrhagic as well as non-haemorrhagic lesions. Conclusions: Low molecular weight (LMWH) at low doses is safe and effective for both non-haemorrhage and haemorrhgic infarct of postpartum cvt with regard to recovery and outcome as compared to control group.

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