Mostafa G Taher, Bashar H Abdullah, Luay E Al Khuri.
Immunohistochemical expression of CD34 as biological marker of angiogenesis and expression of D2-40 as marker of lymphangiogenesis in mucoepidermoid carcinoma of salivary glands.
J Pak Med Students Jan ;2(3):126-33.

BACKGROUND: Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm characterized by the proliferation of epidermis, mucous, and intermediate cells in various proportions. This study evaluates the immunohistochemical expression of CD34 and D2-40 as marker of angiogenesis and lymphangiogenesis of MEC respectively and their correlation with the tumor grade and stage. MATERIALS AND METHODS: We studied 22 salivary gland MEC tissue samples collected between 1972 and 2010. Age, sex, site, stage and histologic grades were reviewed. The samples were immunohistochemically stained with monoclonal antibodies against CD34 and D2-40. RESULTS: The stage of MEC had a significant relationship with Brandwein grading system (P=0.039). The mean of microvessel density count by CD34 immunomarker was (10.74±5.97) with no significant relation to tumor grade or stage (P=0.579, P=0.438).The lymphatic vessel density expressed by D2-40 immunomarker was (18.15±15.92) which was also not significantly related to tumor grade or stage (P=0.573, P=0.773). CONCLUSIONS: Microvessel density and lymph vessel density were not associated with tumor grade or stage. Thus, we found no correlation between the histological grade or tumor stage of MEC and angiogenesis or lymphangiogenesis.

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