Anjum Gulraze, Wesam Kurdi, Maha Tulbah, Faraz Azim Niaz.
Prenatal diagnosis and treatment perspective of fetal hypothyroidism with goiter.
J Coll Physicians Surg Pak Jan ;23(3):216-8.

We describe two cases of fetal goiter in women with no history of thyroid disease. Diagnosis of fetal goiter during antenatal care was made by ultrasound and MRI. Congenital hypothyroidism was confirmed by fetal blood sampling that was treated with weekly intra-amniotic injections of L-thyroxin. One fetus was initially treated with four weekly intra-amniotic injections of 200 µgms of L-thyroxin, later increased to 400 µgms. The other fetus was treated with only three weekly intraamniotic injections of 400 µgms of L-thyroxin. Therapeutic response was monitored by repeated ultrasound and MRI along with fetal blood sampling. At birth, none of the babies had goiter and were put on oral thyroxin. Post-natal studies were suggestive of congenital hypothyroidism due to dyshormogenesis. No abnormality was detected at follow-up. These cases highlight the role of intra-amniotic thyroxine in management of fetal hypothyroidism with goiter.

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