Abdul Latif Jokhio, Abdul Hafeez Dall, Saima Malik, Imtiaz Ali Waggan, Khursheed Ahmed Abbasi.
Effect of sildenafil citrate on testis of adult albino rats.
Pak Paed J Jan ;37(2):112-6.

Objective: To assess the body weight, paired testicular weight and relative tissue weight index (RTWI) of male adult albino rats after the long and short term use of sildenafil citrate. Background: As very little attention has been given to explore the effects of a sildenafil citrate on histological aspects of testes, hence this experimental study was designed to check whether the drug which is being used indiscriminately in our country and abroad is safe or it has any harmful effect on the architecture of rat testis. Study design: Randomized control trial Material & Methods: This study was conducted in departments of Anatomy & Histopathology Shaikh Zayed Hospital Lahore , for a period of six weeks from 02-05-2008 to 17-06-2008. Sample size consisted of 45 animals, divided into Group A (Control), Group B and C (Experimental), Each group was consisting of 15 animals. Physical examination of rats and their testis was done every day by the author himself and recorded. RESULTS: No significant difference was observed in body weight, paired testicular weight and relative tissue weight index of male adult albino rats amongst the three groups under study, i.e control, experimental B and C groups. Conclusion: Sildenafil citrate has no effect on body weight, paired testicular weight and relative tissue weight (Testis) index, hence could be used safely.

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