Kashif Nadeem, Naveed Akhtar, Javed Mirdad Tarar.
Thyroid malignancy in multi nodular goiter; incidence, a retrospective study in southern Punjab.
Professional Med J Jan ;20(4):587-90.

Objectives: To assess the incidence of malignancy in patients with Multinodular goiter in southern Punjab. Study design: A retrospective study. Place & Duration of study: Department of General Surgery, Sheikh Zayed Medical College & Hospital Rahim Yar Khan, from April 2010 to May 2012. Patients and Methods: All patients were presented in OPD with history of Multinodular goiter on clinical examination or USG neck. FNAC of any dominant nodule or suspicious nodule on USG neck was performed. All patients were operated & total thyroidectomies were done in all patients irrespective of the age. We sent all specimens for histopathological examination and reports were collected from department. The whole information collected was entered in a pre designed proforma. Results: During 2 years period, total 141 patients of thyroid disease were seen in OPD out of which 98 patients have Multinodular goiter. Histopathology of these patients showed 10 malignancies & 88 benign. Most of the patients that turned out to be malignant belong to 41-50 years age group. 7 patients were female and 3 were male. Among the malignancies 50% were papillary, 30% were follicular, and 10% were anaplastic carcinoma & lymphomas each. Conclusions: Multinodular goiter (MNG) is the commonest indication of thyroidectomy in iodine deficient areas of Pakistan. This study concludes that don’t consider MNG as a benign disease anymore until proved otherwise.

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