Haider Ali Khan, Muhammad Umar, Hamama Tul Bushra, Gul Nisar, Sara Zia.
Propofol plus midazolam versus propofol alone sedation in therapeutic endoscopic retrograde cholangio pancreatography (ERCP).
J Rawal Med Coll Jan ;17(2):163-6.

Background: To compare Endoscopic Retrograde Cholangio Pancreatography (ERCP) sedation receiving propofol alone and with midazolam in terms of mean propofol dosage and mean recovery time. Methods: In this comparative study, patients undergoing therapeutic ERCP were divided into Group A (Propofol alone) and Group B (Propofol plus Midazolam). Mean propofol dose adjusted to weight and duration of procedure and mean recovery time was compared between the two groups. Results: There were 40 patients in each group; 46.3% (n=37) males and 53.8% (n=43) females. According to ASA class stratification, 43% (n=34) patients were in ASA class I, 41% (n=33) patients in ASA class II and 16% (n=13) patients in ASA class III. The mean dose of propofol was not significantly different between the two groups; 276 ± 124 mg (Group A) vs. 290 ± 115 mg (Group B), p=0.58). The mean adjusted dose when adjusted to weight and duration of procedure also did not significantly differ; 0.08 ± 0.04 (Group A) vs. 0.07 ± 0.03 (Group B), p= 0.38). The recovery time was significantly better with propofol monotherapy; 12 ± 7 min (Group A) vs. 44 ± 13 min (Group B), p=0.0001). Conclusion: In comparison to sedation with propofol and midazolam in ERCP, recovery time from sedation is shorter with propofol monotherapy with no additional propofol dose requirement.

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