Asim Zulfiqar, Abdul Ghani Waseem, Iffat Sultana, Mohammad Masood Savul, Amna Tariq.
Effect of pro-kinetic drugs on post-prandial glycaemic surge in type 2 diabetic patients.
J Rawal Med Coll Jan ;16(2):100-2.

Background: To study the effects of pro-kinetic agents on post-prandial glycaemia in type 2 diabetes mellitus. Methods: In this comparative study one hundred and eighty patient with Type 2 diabetes mellitus and features of gastroparesis were randomly recruited. They were divided randomly into two groups of ninety each. Group I was given oral antidiabetic agents and placebo. Group II was given oral anti-diabetic agents along with domperidone. Mean levels of glycaemic difference. Difference between Premeal and two hours postmeal and glycaemic levels were determined and compared in the two groups. Results :Mean fasting blood sugar of Group I was 168.57 mg/dl and 2 hours postprandial was 296.73 mg/dl. In Group II mean fasting blood sugar was 201.24 mg/dl and mean 2 hours postprandial blood sugar was 296.42 mg/dl. Mean difference in fasting and 2 hours post prandial was 156.38 mg/dl and 114.15 mg/dl, respectively in Group I and II. Conclusion: Mean difference between fasting and 2 hours postprandial blood sugar is significantly low in patients taking prokinetic drugs, as compared to the diabetics not taking pro-kinetic drugs.

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