Iram Tassaduq, Shadab Ahmad Butt, Muhammad Saeed.
Role of ascorbic acid in portal inflammation induced by rifampicin.
J Rawal Med Coll Jan ;16(1):22-4.

Background: To assess the role of ascorbic acid in portal triaditis caused by Rifampicin. Methods: In this experimental study, thirty adult BALB/c mice weighing 35-50 grams were taken. They were kept under standard laboratory conditions of temperature and humidity and light/dark cycle. Animals were given diet pellets. Mice were randomized and divided into three groups (n=10 animals in each group).Group A was given rifampicin in a dose of 100 mg/kg, Group B was given rifampicin 100 mg/kg along with Ascorbic acid 500 mg/kg orally for 6 weeks.Group C was the control group Results: Histological examination of animals revealed significant change in portal triaditis in experimental group having Ascorbic Acid along with Rifampicin. Conclusion: Ascorbic acid has a protective role against Portal Inflammation caused by Rifampicin.

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