To evaluate the relationship of serum FSH in early follicular phase with ovulation, mid-luteal serum progesterone and estradiol. It was a prospective study, carried out over a period of 1 year from August 2000 to August 2001 in Women clinic and fertility advisory center Islamabad.104 women with fertility deprivation were followed during different phases of reproductive cycle by serial sonography and serum hormonal assays. According to serum FSH levels i.e., <= 5, 5-10 and >10 mIU/ml the mean serum FSH levels 3.9±0.1, 6.6±0.3, 11.7±0.4 mIU/ml respectively were during cycle day 1-4, likewise mean FSH levels 3.5±0.2, 6.4±0.3, 13.7±1.7 mIU/ml were during cycle day 5-7. Lesser number of women was noted with increasing FSH levels. The non-significant (p>0.05) increased of ovulation and decreased of involution in women was found with increasing FSH levels, during cycle day 1-4 as compared to cycle day 5-7. Mean mid-luteal / cycle day 21 10.3±1.1 ng/ml serum progesterone rise corresponding to cycle day 1-4 at FSH level > 10 mIU/ml was significantly (p<0.05) higher than cycle day 5-7 at the same level. The higher percentage (82.8%) of women with mid-luteal serum estradiol peak was observed in categorized serum FSH level < 5mIU/ml during cycle day 1-4, while, during cycle day 5-7, higher percentage (77.3%) of women with mid-luteal serum estradiol peak was in categorized serum FSH level 5-10 mIU/ml. Whereas, during cycle day 1-4 mean mid luteal serum estradiol peak level 153.83±17.3 in women with serum FSH level 510 was significantly (p<0.05) increased as compared to mid luteal serum estradiol level 111.0±5.9 in corresponding serum FSH level <= 5 mIU/ml. It is concluted that serum FSH levels < 10 mIU/ml are more predictable for women to have midluteal rise in serum progesterone and estradiol indicating normal ovarian function.
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