Fazali Wahid, Habibur Rehman, Isteraj Khan Shahabi.
Kikuchi's disease: a clinicopathological analysis of 22 cases.
J Med Sci Jan ;19(4):177-80.

Objective: To determine the clinicopathological pattern of Kikuchi’s disease. Material and Methods: This case series study was conducted at the department of Ear, Nose, Throat, Head and Neck Surgery, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar from Jan. 2002 to Dec. 2008. This study includes 22 cases of Kikuchi’s disease. Patients of any age and either sex presenting to E.N.T Department and diagnosed as Kikuchi’s disease were included in this study. These patients were treated with oral prednisolone, antibiotics and analgesics and they were followed at 3 monthly intervals for at least 12 months. The data of these patients were collected on a preformed proforma.The statistical analysis was performed using the statistical program for social sciences (SPSS version 11). Results: Our study included 22 cases of Kikuchi’s disease constituting 13 females and 09 males, with female: male ratio of 1.4:1. The age of the patients ranged from 11-47 years. Most of the patients presented in their 2nd and 3rd decade, followed by patients in their 4th and 5th decade. The clinical features of these patients were mainly lymphadenopathy and fever. The diagnosis of Kikuchi’s disease was made on the basis of fine needle aspiration cytology in 18 cases (81.81%) and 4 cases (18.18%) were diagnosed on lymph node histopathology. These patients were treated with oral prednisolone and antibiotics. Conclusion: While dealing with a young patient with fever and cervical lymphadenopathy, the clinicopathological profile of Kikuchi’s disease must be kept in mind both by clinicians and pathologists to prevent misdiagnosis.

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