Muhammad Bilal, Abdul Janan, Irfanullah, Mushtaq Ahmad.
Occurrence of methicillin resistant staphylococcus aureus (MRSA) in patients requiring reconstructive surgery.
Pak J Surg Jan ;30(4):301-5.

Objectives:Staphylococcus aureus is a signifi cant nosocomial pathogen and the development of resistance to methicillin poses a major threat to its control. Th isstudy was conducted to determine the incidence of methicillin resistant staphylococcus aureus in outdoor patients and its susceptibility to diff erent anti-staphylococcal antibiotics. Study design: Descriptive prospective study. Sett ing and duration: Outpatient department, Plastic Surgery& BurnUnit, Khyber Teaching Hospital Peshawar from August 2011 to July 2014. Methods: A total of 210 patients, of either gender, who presented with septic wounds were included in the study.Swabs were collected from infected wounds and transported in Stuart’s medium. Th e Specimens were inoculated on Blood agar, MacConkey’s agar and nutrient agar and incubated at 37oC for 24 hours. Th e clinical specimens submitt ed at the microbiology laboratory were processed and all methicillin resistant staphylococcus aureus (MRSA)isolates were identifi ed morphologically and biochemically by standard laboratory procedures. All the isolates were studied for their susceptibility and resistance patt ern. Results:Out of 210 patients, 123 (58.57%) were male and 87(41.42%) female with mean ageof 28.5 years. Th e frequency of culture positive cases was 127 (60.47%), of which the frequency of MRSA was 81 (63.77%). Th e frequency of culture negative cases was 83 (39.52%). Th e MRSA were 100% sensitive to linezolid, vancomycin and teicoplanin. Out of them 49.38% were sensitive to fuscidic acid, 19.75% to cotrimoxazole and 30.86% to tetracycline group of antibiotic. Th e organism was found to be 100% resistant to most of commonly prescribed antibiotics. Conclusions:Th e emergence of MRSA is on the rise. Th e organism spreads easily in hospital sett ings and causes higher mortality, morbidity and increased costs. Specifi c precautions and infection control measures must be adopted to prevent and interrupt the spread of MRSA.

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