Javeria Iqbal, Mohammad Abukhatir, Alam Ara Shafi, Ghadah M Alyahya, Bandar N Alharthi.
Hormone receptor status of breast cancer in patients of diff erent age groups, lymph node status histological type and tumor grade, an experience at King Fahad Medical City, Riyadh.
Pak J Surg Jan ;30(4):296-300.

Aim: To see the relationship between receptor status and age of patients, tumor grade, histological type and lymph node involvement in breast cancer patients. Methods: A retrospective review of histopathological reports of breast cancer cases that presented to KFMC over 5 years was made. Results: Total of 345 patients were included.63% of them were triple positive.35% were ER/ PR negative.54% ER/PR positive and 11% were either ER or PR positive. Patients >45yrs were usually ER/PR positive 72.7% as compared to patients of age <45yrs who had more ER/PR negative tumors 39.4 %(p=0.044).On comparison of ER/PR status with grade we found that ER/PR negative tumors were high grade and ER/PR positive were mostly low grade(P=0.001). We also found that HER2 negative tumors were mostly low grade 75 %.( p=0.043). On comparing histological type of tumors with receptor status we found that patients with invasive ductal cancer were mostly ER/PR Negative 91.3 %as compared to ER/ PR positive 87.8% .No correlation was found between receptor status and lymph node status (p=0.961) Conclusion: Most of our breast cancer patients are triple positive. Young patients have more receptor negative tumors as compared to older patients. High grade tumors are mostly receptor status negative as compared to low grade ones.

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