Kalsoom R, Jaffar R, Qureshi N, Aziz F.
A study of p57kip2 expression and morphological findings of complete and partial hydatidiform moles.
Biomedica Jan ;31(1):11-4.

Background: Hydatidiform mole (HM) is classified as complete and partial hydatidiform mole. The incidence of molar pregnancy demonstrated marked geographic and ethnic differences. The diagnosis is based on histopathology, karyotyping and flow cytometry. Objective of the present study was the differentiation and comparison between complete and partial hydatidiform mole on the basis of p57KIP2 expression. This comparative study was conducted in the Department of Pathology, Postgraduate Medical Institute / Lahore General Hospital, Lahore from 1st Jan 2011 to 31st Dec 2013. Methods: The case records of all the molar pregnancy specimens during study period were analyzed regarding patient’s history, clinical examination, morphological features and p57KIP2 expression. The main outcome measures included morphological features and immunohistochemical p57KIP2 expression. Results: There were total of 50 cases which included 15 cases of complete and 35 cases of partial hydatidiform mole on H & E staining which proved to be 17 cases of complete and 33 cases of partial mole on p57KIP2 immunohistochemical expression. The commonest age of presentation of HM was 30 – 39 years. Conclusion: Morphological findings of CHM differ from PHM on the basis of histopathological criteria. Complete hydatidiform mole showed absent expression and partial mole showed positive expression of p57KIP2 immunohistochemical staining. Thus p57KIP2 is a valuable diagnostic tool that could be used to differentiate complete and partial hydatidiform mole.

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