Huang Jiao, Zhang Xianfeng, Han Hui, Malizhen, Zhan Yuhong, Zhang Chu.
A novel mutation, IVS2-2AgG, associated with acute intermittent porphyria in a Chinese family.
J Pak Med Assoc Jan ;65(8):898-900.

Porphyria is a group of disorders caused by the accumulation of porphyrin and porphyrin precursors due to the abnormalities in certain enzymes that normally participate in the production of haem. We report a case of a woman with severe menstruation-related abdominal pain, hyponatraemia, and psychiatric symptoms. Excessive porphobilinogen was found in her urine. A new mutation in intron 2 (IVS2-2AgG), which had never previously been reported in patients with porphyria or in healthy Chinese population, was identified in the heterozygous state in the patient and her mother.

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