Saira Bugti, Altaf Ahmed Sheikh, Nabeel Qamar, Abdul Aziz Sheikh.
A Comparative Study of Pre-operative FNAC with Postoperative Histopathology in the Diagnosis of Breast Lump.
Pak J Surg Jan ;31(1):3-6.

Objective: To evaluate the diagnostic accuracy of Fine Needle Aspiration Cytology (FNAC) for breast lump in comparison of histopathalogical fi ndings. Study Design: Cross sectional study. Place and duration: Th is study was conducted at Department of Pathology, Liaquat University of Medical and Health Sciences (LUM&HS), from 1st January 2012 to 31st July 2012. Methodology: Non probability purposive sampling technique was used for sample collection. Th e samples were 100 cases of Breast lumps. Th e diagnosis was established by Pre-operative FNAC and their accuracy was compared to histopathological diagnosis. Th e samples were collected with the informed consent of the patient. Th e data was entered in the SPSS version 22 and analyzed for the accuracy of FNAC. Results: In total of 100 breast lump cases of both genders, fi ve cases were found diff erent on histopathology, which were previously labeled as benign on FNAC. Th e sensitivity and specifi city of FNAC was 95% and 100% respectively. Similarly true positive cases were 95% and false negative cases were 5%. So the diagnostic accuracy was 95%. Th e positive predict value (PPV) was 100% and Negative predictive value (NPV) was 93.3% Conclusion: FNAC is reliable, easily repeatable and simple diagnostic test. A high sensitivity and positive predict value (PPV) indicates that a positive FNAC in the breast lumps is highly suggestive of defi nite diagnosis of the concerned pathology when compared with the fi nal histology report. Th e high specifi city and a high Negative predictive value (NPV) for malignancy illustrated the high accuracy of FNAC in the diagnosis of malignancy in the breast.

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