Nadeem Hafeez Butt.
Comparison of two commonly used Topical B-Blockers for the control of Raised Intraocular Pressure in once and twice daily dosage.
Pak J Ophthalmol Jan ;11(3):82-5.

A clinical trial of four-month duration was conducted at the Institute of Ophthalmology, Mayo Hospital, Lahore, between June, 1994 and September, 1994. In this trial clinical effectiveness and comparison of 0.5% levobunolol and 0.5% timolol in the reduction of raised intraocular pressure (IOP) was evaluated on 40 patients suffering from primary open angle glaucoma (POAG) or ocular hypertension. Once daily ocular hypotensive effect in contrast to standard twice daily dose was also evaluated. The overall mean decrease in IOP in 0.5% levobunolol group was 5.5 mmHg (21.8%) and it was 5.7 mmHg (21.5%) in 0.5% timolol group, with once daily regime. No systemic side effects like hypotension or bradycardia were noticed. The clinical data suggest that there is no statistical difference in the control of IOP between 0.5% levobunolol and 0.5% timolol and that once daily topical B-blockers are as effective as twice dally B-blockers.

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