Shafi M Jatoi, Khalid Iqbal Talpur, Rasheed Ahmed Memon.
Corneal Ulceration.
Pak J Ophthalmol Jan ;14(3):114-7.

Objective: To determine the incidence, predisposing factors and microbial etiology of corneal ulceration. Design: A prospective study of 97 patients of corneal ulceration registered from January 1995 to December 1995. Setting: indoor patients of general community at the Department of Ophthalmology, Unit-I, Eye Hospital, Liaquat Medical College, Jamshoro/Hyderabad. Subject: Corneal ulceration Main outcome measures: Ulcerative keratitis with chronicity and previous antibiotic treatment. Results: Ninety-seven (9.06%) patients of corneal ulceration were found in 1070 hospital admissions. Corneal ulceration was encountered in all age groups with predominance in males (66 cases, 68.04%) As predisposing factor, corneal trauma was found in 41(42.26%) patients. Of the 97 patients, 66(68.04%) had positive microbial growth, whereas thirty-nine (40.20%) had pure bacterial growth, 17(17.52%) pure fungal growth and 10(10.30%) yielded mixed growth of bacteria and fungi. The most frequent bacterial Isolate was streptococcus pneumonlae (30.76%), whereas amongst fungi, the most frequent isolate (48.14%) was aspergillus species. Conclusion: Leading predisposing factor for the development of corneal ulceration was corneal trauma (42.26%). Failure of cultures (31 cases, 31.95%) was due to the use of previous antibiotic treatment and chronicity of corneal ulcers. Streptococcus pneumonlae (12 of 39 bacterial Isolates, 30.76%) and aspergillus (13 of 27 fungal isolates, 48.14%) were the most frequent causative organisms.

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