Wajeeha Saeed, James F Burke, Ghazi Mirrani, Minisha Sirinivasa, Usman Nabi, Umar Hayat, Zubair Khan, Muhammad Rizwan Sardar.
A Paradigm Shift: The New Novel Oral Anticoagulation Agents.
J Coll Physicians Surg Pak Jan ;26(7):611-9.

Atrial fibrillation (AF) is the most common arrhythmia and represents one-third of the arrhythmia-related hospital admissions in the developed countries. Embolic strokes associated with AF are more severe and disabling. Thromboembolic stroke prevention is a major goal in treatment of AF and Warfarin has successfully served this purpose for many years. Drug-drug interaction and regular monitoring with Warfarin pose a significant challenge where health care system has limited resources; and lack of a well-structured health system, hinders regular International Normalized Ratio (INR) monitoring. Novel oral anticoagulants (NOACs) have opened up a new exciting chapter in the field of anticoagulation in non-valvular atrial fibrillation (NVAF). This review discussed the landmark trials that led to the development of NOACs and explored the potentials of these new agents with simultaneous comparison of Warfarin.

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