Intzar Hussain, Javed Malik, Tariq Khan, Nadeem Riaz, Muhammad Tayyib, Wasif M Kadri.
Additive effect of Latanoprost to topical Beta-Blockers in lowering IOP in Primary Open-Angle Glaucoma and its ocular tolerance.
Pak J Ophthalmol Jan ;16(2):79-81.

This ongoing study was carried out at Glaucoma Research Unit, Eye Unit 1, Services Hospital, Lahore, from Feb. 1999 to date. In this trial, ocular tolerance and additive effect of 0.005% latanoprost to topical 0.5% timolol maleate were evaluated in patients with primary open-angle glaucoma whose intraocular pressure (IOP) was above the individual target level despite maximal topical beta-blocker therapy. 0.005% latanoprost was added once a day in the evening. Forty eyes of 25 patients were included with a mean IOP, before the addition of latanoprost, of 20.28 mmHg. Six eyes presented with IOP in the range of 11 to 16 mmHg, while 25 eyes presented in the range of 17-22 mmHg, and IOP in the range of 23-30 mmHg was observed in 9 eyes. Patients were followed at the 1st 2nd and 3rd months. All the patients had minimum follow-up of three months. Reduction in IOP induced by latanoprost was 3.6 mmHg in the first group at the end of the 1st month. In group 3, reduction in IOP was 7.6 mmHg at the end of 1s` month. Same trends were observed at the end of 2nd and 3`d months. Overall mean reduction in IOP induced by latanoprost was 27% at the end of 1st month, 30% at the end of 2nd month and 33% at the end of 3`d month. IOP remained stable thereafter in those patients who were followed-up for 6 months using latanoprost along with the beta-blocker. A few patients had conjunctival hyperemia, itching, burning and foreign body sensation. These symptoms were mild and transient.

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