Muhammad Ammar Rashid, Muhammad Hussain, Muhammad Irfan Tahir Khan, Aamir Hussain, Ahmed Noeman, Muhammad Ayub.
Frequency of Left Ventricular Diastolic Dysfunction in Normotensive Asymptomatic Type II Diabetic Patients and Its Relationship with Diabetic Control.
J Cardiovascular Dis Jan ;13(2):44-9.

OBJECTIVES: The objectives of this study were to determine the frequency of left ventricular diastolic dysfunction (LVDD) in normotensive asymptomatic type II diabetic patients and to compare the frequency of good diabetic control in normotensive asymptomatic type-II diabetic patients with and without LVDD. MATERIAL AND METHODS:This cross-sectional study was conducted at department of Cardiology, Punjab institute of Cardiology, Lahore from 20/04/2015 to 19/10/2015 (six months). This study involved 200 normotensive asymptomatic type-II diabetic patients. Written informed consent was taken from every patient. RESULTS: The mean age of the patients was 58.00±11.06 years and there were 104 (52%) male and 96 (48%) female patients in the study group. The mean duration of diabetes was 72.92±18.63 months and the mean BMI of the patients was 29.22±3.46 Kg/m2 . 94 (47%) patients were on oral hypoglycemics while 106 (53%) patients were taking insulin. Family history of DM was present in 82 (41%) patients while rest 118 (59%) patients didn’t have a positive family history of DM. Left ventricular diastolic dysfunction was diagnosed in 97 (48.5%) patients while in 103 (51.5%) cases left ventricular function was preserved. 47.5% (n=95) patients had good glycemic control. When compared, the frequency of good glycemic control was significantly higher among patients with preserved left ventricular function (56.3% vs. 38.1%; p=.01) as compared to those with LVDD. When stratified the data to address effect modifiers of LVDD, there was no significant difference of LVDD among various age groups (p=.210), genders (p=.874), and treatment groups (p=.211). However, the frequency of LVDD was significantly higher with increased BMI; 20-25 Kg/ m2 vs. 25-30 Kg/m2 vs. 30-35 Kg/m2 (37.5% vs. 40.6% vs. 58.3%; p=.027), increased duration of disease; 48-59 months vs. 60-71 months vs. 72-83 months vs. 84-95 months vs. 96-108 months (28.1% vs. 43.8% vs. 55.6% vs. 61.1% vs. 71.9%; p=.000), and positive family history (57.3% vs. 42.4%; p=.038). CONCLUSION: The frequency of LVDD was found to be 48.5% in normotensive asymptomatic type-II diabetic patients in local population. Moreover, the frequency of good glycemic control was significantly higher in patients with preserved left ventricular diastolic function as compared to those with LVDD. KEY WORDS: Type-II Diabetes, Glycemic Control, Left Ventricular Diastolic Dysfunction

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