Muhammad Usman Anjum, Muhammad Safdar Khan, Abdul Razzaq Shahid, Syed Humayun Shah.
Urinary tract infections; etiological profile and antimicrobial susceptibility patterns of uropathogens.
Professional Med J Jan ;23(01):010-4.

Urinary tract infections (UTIs) constitute important bacterial disease which contributes to significant morbidity world-wide. Empirical treatment in patients suffering from UTI depends upon the local knowledge of common microorganisms responsible for UTI in that geographical area as well as their antimicrobial susceptibility patterns. Objectives: To determine the frequency and antimicrobial susceptibility of uropathogens which are responsible for urinary tract infections. Study Design: Experimental study. Setting: Department of Pathology, Frontier Medical & Dental College and Mohi Ud Din Islamic Medical College. Period: January 2015 to June 2015. Material & methods: Total of 113 patients were included in the study. Urine samples were cultured on MacConkey’s agar and Cysteine Lactose Electrolyte Deficient (CLED) agar. Micro-organisms were identified using standard tests and antimicrobial susceptibility was checked using modified Kirby Bauer method following Clinical and Laboratory Standards Institute (CLSI) guidelines. Results: The average age of patients was 32.19±16.47 years. Gram negative organisms accounted for majority of cases, about 89 (78.76%) cases. Escherichia coli was the most common micro-organism which was found in 50 (44.24%) cases followed by Staphylococcus aureus in 24 (21.24%), Enterobacter spp. in 19 (16.81%), Klebsiella spp. in 11 (9.73%) and Proteus spp. in 9 (7.96%) cases. E. coli was sensitive to imipenem and ciprofloxacin and was resistant to amoxicillin/clavulanic acid and gentamicin. Conclusion: Gram negative organisms are largely responsible for UTIs and E. coli being the most common etiological agent. E. coli is sensitive to commonly prescribed drugs for UTI like ciprofloxacin.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com