Shumaila Shaikh, Azhar Memon, Muhammad Atif Ata, Haji Khan Khoharo.
Cobalamin deficiency; helicobacter pylori infected patients: a myth or reality.
Professional Med J Jan ;23(2):176-81.

The present study aims to evaluate the serum cobalamin in Helicobacter pylori (H. pylori) infected patients. Study Design: Case control study. Place and Duration: Department of Medicine, Isra University Hospital Hyderabad from March 2013- April 2014. Methodology: A sample of 109 subjects including Helicobacter pylori positive subjects and controls were selected according to study criteria. Centrifugation of blood was performed at 4000 rpm for 10 minutes and sera were stored at -20oC. Blood sera were used for H. pylori serological testing. Blood counting was performed on hematoanalyzer. Cobas e411 analyzer was used for detection of cobalamin. 64 kD H. pylori antigens was detected by ELISA. The data was entered into SPSS version 21.0. (IBM, Incorporation, USA) A 2-tailed p-value of ≤0.05 was considered significant for statistical analysis. Results: Of total 109, 54.1% (n=59) were H. pylori seropositive cases and others were controls i.e. 45.9% (n=50). Cases and controls showed cobalamin levels of 290±49.3 vs. 351±32.9 pg/ml respectively (p=0.0001). Red blood cell indices were found to show statistically significant difference between cases and controls (p=0.001). Conclusion: Serum cobalamin deficiency was noted in both Helicobacter pylori positive and controls, however deficiency was more pronounced in Helicobacter pylori positive subjects.

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