Musarrat Nafees, Muhammad Zahoor Janjua, Muhammad Farooq.
Perchloroethylene induced Nephropathies in albino Rats.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;6:264-72.

To evaluate the effect of perch loroethylene in inducing nephrophaties. 30 adult albino rats of either sex were divided in to three equal groups; Normal control `A`, Sesame Oil Control `B` & Tetrachlcroethylen treated group `C` injected with tetrachloroethylen 3mg/kg for 15 days. On completion of treatment all the animals were sacrificed their kidneys removed , processed for paraffin embedding and stained with H&E, PAS and alcian blue . Tetrachloroethylene induces marked swelling of renal tubular cells with lumina filled with cellular debris and casts. Hyaline fibrinoid droplets were found in proximal tubular cells. Tetrachloroethylene induces , changes suggestive of protenacious nephropathy .

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