Syeda Amber Zaidi, Syed Mohsin Turab, Afzal Qasim, Shah Nawaz Jamali.
Non-steroidal anti-inflammatory drugs; comparative analysis.
Professional Med J Jan ;23(04):460-6.

Objectives: To compare the antinociceptive effects of Aspirin, Diclofenac and Ketorolac in experimental animals. Setting: Animal based study done in the Department of Pharmacology, Hamdard College of Medicine & Dentistry, Hamdard University, Karachi. Period: January to June 2015. Subjects and Methods: This is a comparative study of analgesic efficacy between aspirin, diclofenac and ketorolac. 40 albino rats were taken and divided into 4 equal groups. Group A, B, C and D treated with normal saline, Aspirin, diclofenac and ketorolac respectively. Results: Significant increase in reaction time was observed with aspirin, diclofenac and ketorolac (p<0.001) using hotplate analgesia meter. Increase in tail flick latency was also found with all three drugs. Ketorolac produces 6.7 second increase in tail flick latency. Conclusion: NSAIDs are the first line of management in acute and chronic pain. Ketorolac is more effective than other nonsteroidal anti-inflammatory drugs.

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