Syed Fasih Ahmed Hashmi, Mashooq Ali Dasti, Muhammad Sajid Abbas Jaffri, Hamid Nawaz Ali Memon, Athar Hussain Memon, Zulfiqar Ali Qutrio Baloch, Syed Zulfiquar Ali Shah.
Ischemic heart diseases; homocysteine level in patients.
Professional Med J Jan ;23(04):410-4.

Objectives: To determine the frequency of hyperhomocysteinemia level in patients with ischemic heart diseases. Study Design: Case series study. Setting: Liaquat University Hospital Hyderabad. Period: Six months. Patients and Methods: All the patients with known ischemic heart disease of either sex gave the history of myocardial infarction and echocardiography showed motion wall abnormalities were recruited and entered in the study. After confirmation of IHD, the 2cc venous blood sample was taken in sterilize disposable syringe and sent to laboratory for evaluation of serum homocysteine levels while the data was collected on pre-designed proforma and the data was analyzed in SPSS 16 and the frequency and percentage was calculated. Results: Total one hundred patients with known ischemic cardiac disease were recruited and evaluated for homocysteine level. The mean ±SD for age of patients with ischemic heart diseases was 55.82±10.94. Majority of the patients were males 57% and the male to female cross tabulation was statistically significant (p=0.02). The hyperhomocysteinemia was not statistically significant in relation to age while it is significant in relation to gender (p=0.01). The overall frequency of hyperhomocysteinemia in IHD was 62% with male predominance 66%, of sixty percent hyperhomocysteinemic individuals 41.9% had severe, 37.1% had intermediate and 21% had mild elevated homocysteine level (p=0.02). Conclusion: It was concluded that hyperhomocysteinemia was associated with ischemic heart disease (62%) with advance age and male gender predominance (66%).

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