Musarrat Nafees, Muhammad Zahoor Janjua, Muhammad Farooq.
Effects of Tetrachloroethylene & Vitamin E on Renal Parenchyma of Albino Rats.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;6:288-95.

To evaluate the role of vitamin `E` against tetrachloroethylene induced nephropathies. Fifty adult albino rats of either sex were divided into five equal groups; normal control (A), sesame oil control (A2), tetrachloroethylene treated group (B), experimental group (C) and vitamin `E` control (D), In group C vitamin `E` (10 mg/animal) was injected simultaneously with tetrachloroethylene (3mg/kg) for 15 days. On completion of treatment all the animals were sacrificed. There kindneys removed, processed for paraffin embedding and stained with H & E, PAS and Alcian Blue. Simultaneous administration of vitamin `E` and tetrachloroethylene showed unaltered morphology of renal cortical parenchyma, comparable with that of group A1, A2 and D kidneys, except slight proximal tubular dilatation. Tetrachloroethlene induced nephropathy may partially be prevented by simultaneous administration with vitamin `E` in albino rats.

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