Mazhar Hijazi.
Nicotine induced morphological changes in Rat Testis.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;6:307-13.

To study the morphological changes in the testis of nicotine treated animals. Experimental study of rat testis. Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. Twenty male adult albino rats were divided in two equal groups; normal control group (A) and experimental group (B). In group B, nicotine (1 mg/kg) was injected intraperitoneally. Treatment with Nicotine showed an altered morphology of the rat testis with a significant (P < 0.005) decrease in the count & diameter of seminiferous tubules and also the diameter of interstitial cell nuclei was significantly decreased. There was a highly significant (P<0.001) decrease in the thickness of germinal epithelium and the number of interstitial cell nuclei when compared with that of control animals. On the basis of the results of present study, it is concluded that nicotine does produce its toxic effects on the germ cells and also on the male fertility.

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