Jamila M Naib, Syeda Sitwat Fatima, Talat Naz, Ejaz Hassan Khan.
Frequency of TSH derangement in subfertility workup.
J Med Sci Jan ;22(4):182-4.

Objective: To calculate frequency of thyroid dysfunction as aetiology of subfertility. Material and Methods: A total of 320 infertile women were investigated for infertility and their TSH levels were done. Time period was a total of 9 months from April 2013 to December 2013 in a tertiary care outpatient setup. Those with derangement of TSH were then send for full Thyroid profile. A standardized preform a was filled and results tabulated. The normal range considered was 0.47-4.6u.i.u/ml TSH was done using EMIA (Chemiluminescence micropartical Immunoassay) Abbot Architect analyzer. All patients had at least 1 year of subfertility. Those with known thyroid disease were excluded from the study. Results: Out of 320 subfertile women 27(0.084%) women had raised TSH levels, and 11(0.034%) had low TSH levels. Conclusion: TSH should be done at an early stage of subfertility workup as more than half of the detected patients had subclinical hypothyroidism and missing this problem leads to unnecessary medications, invasive investigations and psychological burden on the couple.

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