Adnan Ahmed, Mushtaque Ali Memon, Muhammad Iqbal.
Carcinoma of larynx; the diagnostic accuracy of computed tomography scan in evaluation of thyroid cartilage invasion.
Professional Med J Jan ;23(09):1045-51.

The objective of this study was to determine the diagnostic accuracy of CT scan in detecting thyroid cartilage invasion by carcinoma of larynx keeping histopathological findings as a gold standard. Study Design: Cross sectional and descriptive study. Setting: Department of Radiology of LUMHS, And Karachi Institute of Radiotherapy & Nuclear Medicine. Period: February 2013 to August 2015. Subjects and Methods: Overall 86 patients were incorporated in this study. All these patients subsequently had their histopathology. The CT outcomes were then contrasted with histopathological results & measures of variables calculated, were based on the results. Results: Fifty patients were men & 36 patients were women. The ages varied from 31 to 65yrs with mean age of 50yrs. The specificity & sensitivity of CT in diagnosing thyroid cartilage invasion was 84.5% and 93.3% respectively. Accurateness of CT in diagnosing thyroid cartilage invasion was 86.05%. Conclusion: The study established the specificity, sensitivity, negative as well as positive predictive value and accuracy of CT scan for the detection of thyroid cartilage invasion as 84.5%, 93.3%, 98.4%, 56% and 86.05% respectively. Very low negative predictive value was found in patients of age more than 50 years

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